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Molecular Properties, Functional Mechanisms, and Applications of Sliced siRNA
Using pre-miR-451 as a model molecule, we have characterized the general molecular properties of small hairpin RNAs that are processed into potent small interfering RNAs (siRNA) by Argonaute2 (Ago2). The Ago2-sliced siRNAs (sli-siRNAs) have the same silencing potency as the classical Dicer diced siR...
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| Publicado en: | Mol Ther Nucleic Acids |
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| Autores principales: | , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Nature Publishing Group
2015
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4345305/ https://ncbi.nlm.nih.gov/pubmed/25602583 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mtna.2014.73 |
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