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Molecular Properties, Functional Mechanisms, and Applications of Sliced siRNA

Using pre-miR-451 as a model molecule, we have characterized the general molecular properties of small hairpin RNAs that are processed into potent small interfering RNAs (siRNA) by Argonaute2 (Ago2). The Ago2-sliced siRNAs (sli-siRNAs) have the same silencing potency as the classical Dicer diced siR...

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Detalhes bibliográficos
Publicado no:Mol Ther Nucleic Acids
Main Authors: Sun, Guihua, Yeh, Spencer Yele, Yuan, Christine Wan-Yin, Chiu, Margaret Jean-Yih, Yung, Bryan Shing Hei, Yen, Yun
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4345305/
https://ncbi.nlm.nih.gov/pubmed/25602583
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mtna.2014.73
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