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Rational design of new NO and redox sensitivity into connexin26 hemichannels

CO(2) directly opens hemichannels of connexin26 (Cx26) by carbamylating K125, thereby allowing salt bridge formation with R104 of the neighbouring subunit in the connexin hexamer. The formation of the inter-subunit carbamate bridges within the hexameric hemichannel traps it in the open state. Here,...

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Bibliografski detalji
Izdano u:Open Biol
Glavni autori: Meigh, Louise, Cook, Daniel, Zhang, Jie, Dale, Nicholas
Format: Artigo
Jezik:Inglês
Izdano: The Royal Society 2015
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4345282/
https://ncbi.nlm.nih.gov/pubmed/25673329
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1098/rsob.140208
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