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Inhibition of the CXCL12/CXCR4 chemokine axis with AMD3100, a CXCR4 small molecule inhibitor, worsens murine hepatic injury

AIM: Activation of hepatic stellate cells and development of chronic inflammation are two key features in the progression of hepatic fibrosis. We have shown that in vitro activated stellate cells increase their expression of CXCL12 as well as the receptor CXCR4 and that receptor engagement promotes...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Hepatol Res
Prif Awduron: Saiman, Yedidya, Jiao, JingJing, Fiel, M. Isabel, Friedman, Scott L., Aloman, Costica, Bansal, Meena B.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2014
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4344928/
https://ncbi.nlm.nih.gov/pubmed/25163538
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/hepr.12411
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