Rapid Deterioration of Insulin Secretion in Obese Adolescents Preceding the Onset of Type 2 Diabetes

OBJECTIVE: To identify pathophysiologic changes that lead to the onset of type 2 diabetes (T2DM) in adolescents. STUDY DESIGN: Obese adolescents with NGT (n=41) were studied longitudinally over 4 years with serial measure of the acute insulin response to IV glucose (AIR(g)) as well as proinsulin (PI...

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Опубликовано в: :J Pediatr
Главные авторы: Elder, Deborah A., Hornung, Lindsey N., Herbers, Patricia M., Prigeon, Ron, Woo, Jessica G., D'Alessio, David A.
Формат: Artigo
Язык:Inglês
Опубликовано: 2014
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4344881/
https://ncbi.nlm.nih.gov/pubmed/25557969
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jpeds.2014.11.029
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