Endonuclease III and endonuclease VIII conditionally targeted into mitochondria enhance mitochondrial DNA repair and cell survival following oxidative stress

Mitochondrial DNA (mtDNA) is exposed to reactive oxygen species (ROS) produced during oxidative phosphorylation. Accumulation of several kinds of oxidative lesions, including oxidized pyrimidines, in mtDNA may lead to structural genomic alterations, mitochondrial dysfunction and associated degenerat...

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Detalhes bibliográficos
Main Authors: Rachek, Lyudmila I., Grishko, Valentina I., Alexeyev, Mikhail F., Pastukh, Viktoriya V., LeDoux, Susan P., Wilson, Glenn L.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2004
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC434452/
https://ncbi.nlm.nih.gov/pubmed/15199172
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkh648
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