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Endonuclease III and endonuclease VIII conditionally targeted into mitochondria enhance mitochondrial DNA repair and cell survival following oxidative stress

Mitochondrial DNA (mtDNA) is exposed to reactive oxygen species (ROS) produced during oxidative phosphorylation. Accumulation of several kinds of oxidative lesions, including oxidized pyrimidines, in mtDNA may lead to structural genomic alterations, mitochondrial dysfunction and associated degenerat...

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Autors principals: Rachek, Lyudmila I., Grishko, Valentina I., Alexeyev, Mikhail F., Pastukh, Viktoriya V., LeDoux, Susan P., Wilson, Glenn L.
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2004
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC434452/
https://ncbi.nlm.nih.gov/pubmed/15199172
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkh648
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