Effects of physiological self-crowding of DNA on shape and biological properties of DNA molecules with various levels of supercoiling

DNA in bacterial chromosomes and bacterial plasmids is supercoiled. DNA supercoiling is essential for DNA replication and gene regulation. However, the density of supercoiling in vivo is circa twice smaller than in deproteinized DNA molecules isolated from bacteria. What are then the specific advant...

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Bibliografske podrobnosti
izdano v:Nucleic Acids Res
Main Authors: Benedetti, Fabrizio, Japaridze, Aleksandre, Dorier, Julien, Racko, Dusan, Kwapich, Robert, Burnier, Yannis, Dietler, Giovanni, Stasiak, Andrzej
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2015
Teme:
Structural Biology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4344501/
https://ncbi.nlm.nih.gov/pubmed/25653164
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkv055
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