Cholesterol loading re-programs the miR-143/145-myocardin axis to convert aortic smooth muscle cells to a dysfunctional macrophage-like phenotype

OBJECTIVE: We previously showed that cholesterol loading in vitro converts mouse aortic vascular smooth muscle cells (VSMC) from a contractile state to one resembling macrophages. In human and mouse atherosclerotic plaques it has become appreciated that ~40% of cells classified as macrophages by his...

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Publicado en:Arterioscler Thromb Vasc Biol
Main Authors: Vengrenyuk, Yuliya, Nishi, Hitoo, Long, Xiaochun, Ouimet, Mireille, Savji, Nazir, Martinez, Fernando O., Cassella, Courtney P., Moore, Kathryn J., Ramsey, Stephen A., Miano, Joseph M., Fisher, Edward A.
Formato: Artigo
Idioma:Inglês
Publicado: 2015
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4344402/
https://ncbi.nlm.nih.gov/pubmed/25573853
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.114.304029
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