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Molecular modulation of the copper and cisplatin transport function of CTR1 and its interaction with IRS-4
The copper influx transporter CTR1 is also a major influx transporter for cisplatin (cDDP) in tumor cells. It influences the cytotoxicity of cDDP both in vivo and in vitro. Whereas Cu triggers internalization of CTR1 from the plasma membrane, cDDP does not. To investigate the mechanisms of these eff...
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| Veröffentlicht in: | Biochem Pharmacol |
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| Hauptverfasser: | , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2014
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4343213/ https://ncbi.nlm.nih.gov/pubmed/24967972 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2014.06.019 |
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