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Dynamics of gene circuits shapes evolvability

To what extent does the dynamical mechanism producing a specific biological phenotype bias the ability to evolve into novel phenotypes? We use the interpretation of a morphogen gradient into a single stripe of gene expression as a model phenotype. Although there are thousands of three-gene circuit t...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Jiménez, Alba, Cotterell, James, Munteanu, Andreea, Sharpe, James
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2015
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4343095/
https://ncbi.nlm.nih.gov/pubmed/25646408
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1411065112
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