Interleukin-1 loop model for pathogenesis of Langerhans cell histiocytosis

We propose Langerhans cell histiocytosis (LCH) is an inflammatory process that is prolonged by mutations. We hypothesize that Merkel cell polyomavirus (MCPyV) infection triggers an interleukin-1 (IL-1) activation loop that underlies the pathogenesis of LCH. Langerhans cells (LCs) are antigen present...

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Bibliografiske detaljer
Udgivet i:Cell Commun Signal
Main Authors: Murakami, Ichiro, Matsushita, Michiko, Iwasaki, Takeshi, Kuwamoto, Satoshi, Kato, Masako, Nagata, Keiko, Horie, Yasushi, Hayashi, Kazuhiko, Imamura, Toshihiko, Morimoto, Akira, Imashuku, Shinsaku, Gogusev, Jean, Jaubert, Francis, Takata, Katsuyoshi, Oka, Takashi, Yoshino, Tadashi
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2015
Fag:
Review
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4343072/
https://ncbi.nlm.nih.gov/pubmed/25889448
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12964-015-0092-z
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