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SPR4-peptide Alters Bone Metabolism of Normal and HYP Mice
CONTEXT: ASARM-peptides are substrates and ligands for PHEX, the gene responsible for X-linked hypophosphatemic rickets (HYP). PHEX binds to the DMP1-ASARM-motif to form a trimeric-complex with α(5)β(3)-integrin on the osteocyte surface and this suppresses FGF23 expression. ASARM-peptide disruption...
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Publicado no: | Bone |
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Main Authors: | , , |
Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
2014
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4342984/ https://ncbi.nlm.nih.gov/pubmed/25460577 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bone.2014.11.011 |
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