Conformational Changes Induced in Dihydrofolate Reductase by Folates, Pyridine Nucleotide Coenzymes, and Methotrexate

Dihydrofolate reductase (EC 1.5.1.3; 5,6,7,8-tetrahydrofolate:NADP(+) oxidoreductase) from antifolate-resistant Lactobacillus casei has been isolated in pure form and examined in solution by high resolution proton magnetic resonance spectroscopy. The 220 MHz proton magnetic resonance spectrum of thi...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Pastore, Edward J., Kisliuk, Roy L., Plante, Laurence T., Wright, John M., Kaplan, Nathan O.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 1974
Assuntos:
Biological Sciences: Biochemistry
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC434281/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/4154440/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.71.10.3849
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