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The Effects of Streptomycin or Dihydrostreptomycin Binding to 16S RNA or to 30S Ribosomal Subunits

Evidence is presented suggesting that streptomycin binds to 16S RNA or to 30S ribosomal subunits at the same topographical site located on the RNA chain. The equally bactericidal dihydrostreptomycin binds to the same site as streptomycin but with lower affinity. The effect of drug binding to 16S RNA...

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發表在:Proc Natl Acad Sci U S A
Main Authors: Garvin, Robert T., Biswas, Debajit K., Gorini, Luigi
格式: Artigo
語言:Inglês
出版: National Academy of Sciences 1974
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在線閱讀:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC434274/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/4139702/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.71.10.3814
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