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Ligand Binding Pocket Formed by Evolutionarily Conserved Residues in the Glucagon-like Peptide-1 (GLP-1) Receptor Core Domain

Glucagon-like peptide-1 (GLP-1) plays a pivotal role in glucose homeostasis through its receptor GLP1R. Due to its multiple beneficial effects, GLP-1 has gained great attention for treatment of type 2 diabetes and obesity. However, little is known about the molecular mechanism underlying the interac...

وصف كامل

محفوظ في:
التفاصيل البيبلوغرافية
الحاوية / القاعدة:J Biol Chem
المؤلفون الرئيسيون: Moon, Mi Jin, Lee, Yoo-Na, Park, Sumi, Reyes-Alcaraz, Arfaxad, Hwang, Jong-Ik, Millar, Robert Peter, Choe, Han, Seong, Jae Young
التنسيق: Artigo
اللغة:Inglês
منشور في: American Society for Biochemistry and Molecular Biology 2015
الموضوعات:
الوصول للمادة أونلاين:https://ncbi.nlm.nih.gov/pmc/articles/PMC4342481/
https://ncbi.nlm.nih.gov/pubmed/25561730
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.612606
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