Intra-S-Phase Checkpoint Activation by Direct CDK2 Inhibition

To ensure proper progression through a cell cycle, checkpoints have evolved to play a surveillance role in maintaining genomic integrity. In this study, we demonstrate that loss of CDK2 activity activates an intra-S-phase checkpoint. CDK2 inhibition triggers a p53-p21 response via ATM- and ATR-depen...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Zhu, Yonghong, Alvarez, Carmen, Doll, Ronald, Kurata, Hirokazu, Schebye, Xiao Min, Parry, David, Lees, Emma
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2004
Assuntos:
Cell Growth and Development
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC434231/
https://ncbi.nlm.nih.gov/pubmed/15226429
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.24.14.6268-6277.2004
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados