Oral Efficacy of a Respiratory Syncytial Virus Inhibitor in Rodent Models of Infection

BMS-433771 is a potent inhibitor of respiratory syncytial virus (RSV) replication in vitro. Mechanism of action studies have demonstrated that BMS-433771 halts virus entry through inhibition of F protein-mediated membrane fusion. BMS-433771 also exhibited in vivo efficacy following oral administrati...

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Veröffentlicht in:	Antimicrob Agents Chemother
Hauptverfasser:	Cianci, Christopher, Genovesi, Eugene V., Lamb, Lucinda, Medina, Ivette, Yang, Zheng, Zadjura, Lisa, Yang, Hyekyung, D'Arienzo, Celia, Sin, Ny, Yu, Kuo-Long, Combrink, Keith, Li, Zhufang, Colonno, Richard, Meanwell, Nicholas, Clark, Junius, Krystal, Mark
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology (ASM) 2004
Schlagworte:	Antiviral Agents
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC434195/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15215093/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.48.7.2448-2454.2004
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