Oral Efficacy of a Respiratory Syncytial Virus Inhibitor in Rodent Models of Infection

BMS-433771 is a potent inhibitor of respiratory syncytial virus (RSV) replication in vitro. Mechanism of action studies have demonstrated that BMS-433771 halts virus entry through inhibition of F protein-mediated membrane fusion. BMS-433771 also exhibited in vivo efficacy following oral administrati...

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Hlavní autoři: Cianci, Christopher, Genovesi, Eugene V., Lamb, Lucinda, Medina, Ivette, Yang, Zheng, Zadjura, Lisa, Yang, Hyekyung, D'Arienzo, Celia, Sin, Ny, Yu, Kuo-Long, Combrink, Keith, Li, Zhufang, Colonno, Richard, Meanwell, Nicholas, Clark, Junius, Krystal, Mark
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2004
Témata:
Antiviral Agents
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC434195/
https://ncbi.nlm.nih.gov/pubmed/15215093
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.48.7.2448-2454.2004
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