The Antimalarial Potential of 4-Quinolinecarbinolamines May Be Limited due to Neurotoxicity and Cross-Resistance in Mefloquine-Resistant Plasmodium falciparum Strains

The clinical potential of mefloquine has been compromised by reports of adverse neurological effects. A series of 4-quinolinecarbinolamines were compared in terms of neurotoxicity and antimalarial activity in an attempt to identify replacement drugs. Neurotoxicity (MTT [thiazolyl blue reduction] ass...

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Udgivet i:Antimicrob Agents Chemother
Main Authors: Dow, Geoffrey S., Koenig, Michael L., Wolf, Lesley, Gerena, Lucia, Lopez-Sanchez, Miriam, Hudson, Thomas H., Bhattacharjee, Apurba K.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2004
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Mechanisms of Action: Physiological Effects
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC434181/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15215119/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.48.7.2624-2632.2004
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