The Antimalarial Potential of 4-Quinolinecarbinolamines May Be Limited due to Neurotoxicity and Cross-Resistance in Mefloquine-Resistant Plasmodium falciparum Strains

The clinical potential of mefloquine has been compromised by reports of adverse neurological effects. A series of 4-quinolinecarbinolamines were compared in terms of neurotoxicity and antimalarial activity in an attempt to identify replacement drugs. Neurotoxicity (MTT [thiazolyl blue reduction] ass...

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Autors principals: Dow, Geoffrey S., Koenig, Michael L., Wolf, Lesley, Gerena, Lucia, Lopez-Sanchez, Miriam, Hudson, Thomas H., Bhattacharjee, Apurba K.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2004
Matèries:
Mechanisms of Action: Physiological Effects
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC434181/
https://ncbi.nlm.nih.gov/pubmed/15215119
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.48.7.2624-2632.2004
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