The acute neurotoxicity of mefloquine may be mediated through a disruption of calcium homeostasis and ER function in vitro

BACKGROUND: There is no established biochemical basis for the neurotoxicity of mefloquine. We investigated the possibility that the acute in vitro neurotoxicity of mefloquine might be mediated through a disruptive effect of the drug on endoplasmic reticulum (ER) calcium homeostasis. METHODS: Laser s...

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Detalhes bibliográficos

Publicado no:	Malar J
Principais autores:	Dow, Geoffrey S, Hudson, Thomas H, Vahey, Maryanne, Koenig, Michael L
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2003
Assuntos:	Research
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC194860/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12848898/ https://ncbi.nlm.nih.govhttps://doi.org/10.1186/1475-2875-2-14
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