Candida glabrata erg1 Mutant with Increased Sensitivity to Azoles and to Low Oxygen Tension

A Candida glabrata erg1 (Cgerg1) mutant, CgTn201S, was identified by transposon mutagenesis and by increased fluconazole susceptibility. CgERG1 encodes a 489-amino-acid protein which, on the basis of its homology with Saccharomyces cerevisiae ERG1, is a squalene epoxidase essential for ergosterol sy...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Tsai, Huei-Fung, Bard, Martin, Izumikawa, Koichi, Krol, Anna A., Sturm, Aaron M., Culbertson, Nicholas T., Pierson, Charles A., Bennett, John E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2004
Assuntos:
Mechanisms of Action: Physiological Effects
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC434157/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15215098/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.48.7.2483-2489.2004
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