Exchanging the Yellow Fever Virus Envelope Proteins with Modoc Virus prM and E Proteins Results in a Chimeric Virus That Is Neuroinvasive in SCID Mice

A chimeric flavivirus infectious cDNA was constructed by exchanging the premembrane (prM) and envelope (E) genes of the yellow fever virus vaccine strain 17D (YF17D) with the corresponding genes of Modoc virus (MOD). This latter virus belongs to the cluster of the “not-known vector” flaviviruses and...

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Bibliographic Details
Main Authors: Charlier, Nathalie, Molenkamp, Richard, Leyssen, Pieter, Paeshuyse, Jan, Drosten, Christian, Panning, Marcus, Clercq, Erik De, Bredenbeek, Peter J., Neyts, Johan
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 2004
Subjects:
Pathogenesis and Immunity
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC434118/
https://ncbi.nlm.nih.gov/pubmed/15220415
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.78.14.7418-7426.2004
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