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Biased Hypermutagenesis Associated with Mutations in an Untranslated Hairpin of an RNA Virus
The mutation frequency of Turnip crinkle virus can increase 12-fold without inducing error catastrophe. Lesions in a hairpin repressor frequently reverted and led to second-site alterations biased for specific mutations. These results suggest that the hairpin may also function as an RNA chaperone to...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Microbiology
2004
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC434097/ https://ncbi.nlm.nih.gov/pubmed/15220455 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.78.14.7813-7817.2004 |
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