Programmed Evolution for Optimization of Orthogonal Metabolic Output in Bacteria

Current use of microbes for metabolic engineering suffers from loss of metabolic output due to natural selection. Rather than combat the evolution of bacterial populations, we chose to embrace what makes biological engineering unique among engineering fields – evolving materials. We harnessed bacter...

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Veröffentlicht in:PLoS One
Hauptverfasser: Eckdahl, Todd T., Campbell, A. Malcolm, Heyer, Laurie J., Poet, Jeffrey L., Blauch, David N., Snyder, Nicole L., Atchley, Dustin T., Baker, Erich J., Brown, Micah, Brunner, Elizabeth C., Callen, Sean A., Campbell, Jesse S., Carr, Caleb J., Carr, David R., Chadinha, Spencer A., Chester, Grace I., Chester, Josh, Clarkson, Ben R., Cochran, Kelly E., Doherty, Shannon E., Doyle, Catherine, Dwyer, Sarah, Edlin, Linnea M., Evans, Rebecca A., Fluharty, Taylor, Frederick, Janna, Galeota-Sprung, Jonah, Gammon, Betsy L., Grieshaber, Brandon, Gronniger, Jessica, Gutteridge, Katelyn, Henningsen, Joel, Isom, Bradley, Itell, Hannah L., Keffeler, Erica C., Lantz, Andrew J., Lim, Jonathan N., McGuire, Erin P., Moore, Alexander K., Morton, Jerrad, Nakano, Meredith, Pearson, Sara A., Perkins, Virginia, Parrish, Phoebe, Pierson, Claire E., Polpityaarachchige, Sachith, Quaney, Michael J., Slattery, Abagael, Smith, Kathryn E., Spell, Jackson, Spencer, Morgan, Taye, Telavive, Trueblood, Kamay, Vrana, Caroline J., Whitesides, E. Tucker
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2015
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4340930/
https://ncbi.nlm.nih.gov/pubmed/25714374
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0118322
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