Programmed Evolution for Optimization of Orthogonal Metabolic Output in Bacteria

Current use of microbes for metabolic engineering suffers from loss of metabolic output due to natural selection. Rather than combat the evolution of bacterial populations, we chose to embrace what makes biological engineering unique among engineering fields – evolving materials. We harnessed bacter...

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Publicat a:PLoS One
Autors principals: Eckdahl, Todd T., Campbell, A. Malcolm, Heyer, Laurie J., Poet, Jeffrey L., Blauch, David N., Snyder, Nicole L., Atchley, Dustin T., Baker, Erich J., Brown, Micah, Brunner, Elizabeth C., Callen, Sean A., Campbell, Jesse S., Carr, Caleb J., Carr, David R., Chadinha, Spencer A., Chester, Grace I., Chester, Josh, Clarkson, Ben R., Cochran, Kelly E., Doherty, Shannon E., Doyle, Catherine, Dwyer, Sarah, Edlin, Linnea M., Evans, Rebecca A., Fluharty, Taylor, Frederick, Janna, Galeota-Sprung, Jonah, Gammon, Betsy L., Grieshaber, Brandon, Gronniger, Jessica, Gutteridge, Katelyn, Henningsen, Joel, Isom, Bradley, Itell, Hannah L., Keffeler, Erica C., Lantz, Andrew J., Lim, Jonathan N., McGuire, Erin P., Moore, Alexander K., Morton, Jerrad, Nakano, Meredith, Pearson, Sara A., Perkins, Virginia, Parrish, Phoebe, Pierson, Claire E., Polpityaarachchige, Sachith, Quaney, Michael J., Slattery, Abagael, Smith, Kathryn E., Spell, Jackson, Spencer, Morgan, Taye, Telavive, Trueblood, Kamay, Vrana, Caroline J., Whitesides, E. Tucker
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2015
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4340930/
https://ncbi.nlm.nih.gov/pubmed/25714374
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0118322
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