Increased Risk of Genetic and Epigenetic Instability in Human Embryonic Stem Cells Associated with Specific Culture Conditions

The self-renewal and differentiation capacities of human pluripotent stem cells (hPSCs) make them a promising source of material for cell transplantation therapy, drug development, and studies of cellular differentiation and development. However, the large numbers of cells necessary for many of thes...

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Udgivet i:PLoS One
Main Authors: Garitaonandia, Ibon, Amir, Hadar, Boscolo, Francesca Sesillo, Wambua, Gerald K., Schultheisz, Heather L., Sabatini, Karen, Morey, Robert, Waltz, Shannon, Wang, Yu-Chieh, Tran, Ha, Leonardo, Trevor R., Nazor, Kristopher, Slavin, Ileana, Lynch, Candace, Li, Yingchun, Coleman, Ronald, Gallego Romero, Irene, Altun, Gulsah, Reynolds, David, Dalton, Stephen, Parast, Mana, Loring, Jeanne F., Laurent, Louise C.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2015
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4340884/
https://ncbi.nlm.nih.gov/pubmed/25714340
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0118307
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