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Structural Basis for Competitive Inhibition of eIF4G-Mnk1 Interaction by the Adenovirus 100-Kilodalton Protein

Translation of most cellular mRNAs involves cap binding by the translation initiation complex. Among this complex of proteins are cap-binding protein eIF4E and the eIF4E kinase Mnk1. Cap-dependent mRNA translation generally correlates with Mnk1 phosphorylation of eIF4E when both are bound to eIF4G....

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Autori principali: Cuesta, Rafael, Xi, Qiaoran, Schneider, Robert J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2004
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC434077/
https://ncbi.nlm.nih.gov/pubmed/15220445
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.78.14.7707-7716.2004
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