The Quinone Methide Aurin Is a Heat Shock Response Inducer That Causes Proteotoxic Stress and Noxa-dependent Apoptosis in Malignant Melanoma Cells

Pharmacological induction of proteotoxic stress is rapidly emerging as a promising strategy for cancer cell-directed chemotherapeutic intervention. Here, we describe the identification of a novel drug-like heat shock response inducer for the therapeutic induction of proteotoxic stress targeting mali...

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Veröffentlicht in:J Biol Chem
Hauptverfasser: Davis, Angela L., Qiao, Shuxi, Lesson, Jessica L., Rojo de la Vega, Montserrat, Park, Sophia L., Seanez, Carol M., Gokhale, Vijay, Cabello, Christopher M., Wondrak, Georg T.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2015
Schlagworte:
Cell Biology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4340407/
https://ncbi.nlm.nih.gov/pubmed/25477506
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.592626
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