The Interplay of Protein Kinase A and Perilipin 5 Regulates Cardiac Lipolysis

Defective lipolysis in mice lacking adipose triglyceride lipase provokes severe cardiac steatosis and heart dysfunction, markedly shortening life span. Similarly, cardiac muscle (CM)-specific Plin5 overexpression (CM-Plin5) leads to severe triglyceride (TG) accumulation in cardiomyocytes via impairi...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Pollak, Nina M., Jaeger, Doris, Kolleritsch, Stephanie, Zimmermann, Robert, Zechner, Rudolf, Lass, Achim, Haemmerle, Guenter
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2015
Subjects:
Metabolism
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4340377/
https://ncbi.nlm.nih.gov/pubmed/25418045
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.604744
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