Cardiac-specific overexpression of perilipin 5 provokes severe cardiac steatosis via the formation of a lipolytic barrier

Cardiac triacylglycerol (TG) catabolism critically depends on the TG hydrolytic activity of adipose triglyceride lipase (ATGL). Perilipin 5 (Plin5) is expressed in cardiac muscle (CM) and has been shown to interact with ATGL and its coactivator comparative gene identification-58 (CGI-58). Furthermor...

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Detalhes bibliográficos
Main Authors: Pollak, Nina M., Schweiger, Martina, Jaeger, Doris, Kolb, Dagmar, Kumari, Manju, Schreiber, Renate, Kolleritsch, Stephanie, Markolin, Philipp, Grabner, Gernot F., Heier, Christoph, Zierler, Kathrin A., Rülicke, Thomas, Zimmermann, Robert, Lass, Achim, Zechner, Rudolf, Haemmerle, Guenter
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3605985/
https://ncbi.nlm.nih.gov/pubmed/23345410
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M034710
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