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Anticancer/Antiviral Agent Akt Inhibitor-IV Massively Accumulates in Mitochondria and Potently Disrupts Cellular Bioenergetics
[Image: see text] Inhibitors of the PI3-kinase/Akt (protein kinase B) pathway are under investigation as anticancer and antiviral agents. Akt inhibitor-IV (ChemBridge 5233705, CAS 681281-88-9, AKTIV), a small molecule reported to inhibit this pathway, exhibits potent anticancer and broad-spectrum an...
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| Udgivet i: | ACS Chem Biol |
|---|---|
| Main Authors: | , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Chemical
Society
2014
|
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4340353/ https://ncbi.nlm.nih.gov/pubmed/25415586 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb500856c |
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