A lipidomic screen of hyperglycemia-treated HRECs links 12/15-Lipoxygenase to microvascular dysfunction during diabetic retinopathy via NADPH oxidase

Retinal hyperpermeability and subsequent macular edema is a cardinal feature of early diabetic retinopathy (DR). Here, we investigated the role of bioactive lipid metabolites, in particular 12/15-lipoxygenase (LOX)-derived metabolites, in this process. LC/MS lipidomic screen of human retinal endothe...

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Bibliografiske detaljer
Udgivet i:J Lipid Res
Main Authors: Ibrahim, Ahmed S., Elshafey, Sally, Sellak, Hassan, Hussein, Khaled A., El-Sherbiny, Mohamed, Abdelsaid, Mohammed, Rizk, Nasser, Beasley, Selina, Tawfik, Amany M., Smith, Sylvia B., Al-Shabrawey, Mohamed
Format: Artigo
Sprog:Inglês
Udgivet: The American Society for Biochemistry and Molecular Biology 2015
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Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4340307/
https://ncbi.nlm.nih.gov/pubmed/25598081
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M056069
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