12/15-Lipoxygenase-dependent ROS production is required for diet-induced endothelial barrier dysfunction

To understand the mechanisms of 15(S)-HETE-induced endothelial cell (EC) barrier dysfunction, we examined the role of xanthine oxidase (XO). 15(S)-HETE induced junction adhesion molecule A (JamA) phosphorylation on Y164, Y218, and Y280 involving XO-mediated reactive oxygen species production and Src...

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Detalhes bibliográficos
Publicado no:J Lipid Res
Main Authors: Chattopadhyay, Rima, Tinnikov, Alexander, Dyukova, Elena, Singh, Nikhlesh K., Kotla, Sivareddy, Mobley, James A., Rao, Gadiparthi N.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Biochemistry and Molecular Biology 2015
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4340304/
https://ncbi.nlm.nih.gov/pubmed/25556764
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M055566
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