Vascular Endothelial Tight Junctions and Barrier Function Are Disrupted by 15(S)-Hydroxyeicosatetraenoic Acid Partly via Protein Kinase Cϵ-mediated Zona Occludens-1 Phosphorylation at Threonine 770/772

Disruption of tight junctions (TJs) perturbs endothelial barrier function and promotes inflammation. Previously, we have shown that 15(S)-hydroxyeicosatetraenoic acid (15(S)-HETE), the major 15-lipoxygenase 1 (15-LO1) metabolite of arachidonic acid, by stimulating zona occludens (ZO)-2 tyrosine phos...

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Detalhes bibliográficos
Main Authors: Chattopadhyay, Rima, Dyukova, Elena, Singh, Nikhlesh K., Ohba, Motoi, Mobley, James A., Rao, Gadiparthi N.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3916520/
https://ncbi.nlm.nih.gov/pubmed/24338688
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.528190
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