Thiostrepton Inhibition of Initiation Factor 1 Activity in Polypeptide Chain Initiation in Escherichia coli

Thiostrepton, a peptide antibiotic, inhibits the GTP-dependent 70S initiation complex formation (as measured by binding of fMet-tRNA to ribosomes and concomitant hydrolysis of GTP) only when initiation factor 1 is present to permit catalytic recycling of initiation factor 2 in the initiation reactio...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Sarkar, Probir, Stringer, Evan A., Maitra, Umadas
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 1974
Soggetti:	Biological Sciences: Biochemistry
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC434024/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/4612536/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.71.12.4986
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