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Kinetics and Mechanism of Deoxyhemoglobin S Gelation: A New Approach to Understanding Sickle Cell Disease

We report the results of a kinetic investigation on the gelation of purified deoxyhemoglobin S. Gelation was induced by raising the temperature and was monitored by measuring both the heat absorbed, with a microcalorimeter, and the appearance of linear birefringence, with a microspectrophotometer. T...

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Publicat a:Proc Natl Acad Sci U S A
Autors principals: Hofrichter, James, Ross, Philip D., Eaton, William A.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 1974
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Accés en línia:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC433999/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/4531026/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.71.12.4864
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