Exploiting light chains for the scalable generation and platform purification of native human bispecific IgG

Bispecific antibodies enable unique therapeutic approaches but it remains a challenge to produce them at the industrial scale, and the modifications introduced to achieve bispecificity often have an impact on stability and risk of immunogenicity. Here we describe a fully human bispecific IgG devoid...

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Veröffentlicht in:Nat Commun
Hauptverfasser: Fischer, Nicolas, Elson, Greg, Magistrelli, Giovanni, Dheilly, Elie, Fouque, Nicolas, Laurendon, Amélie, Gueneau, Franck, Ravn, Ulla, Depoisier, Jean-François, Moine, Valery, Raimondi, Sylvain, Malinge, Pauline, Di Grazia, Laura, Rousseau, François, Poitevin, Yves, Calloud, Sébastien, Cayatte, Pierre-Alexis, Alcoz, Mathias, Pontini, Guillemette, Fagète, Séverine, Broyer, Lucile, Corbier, Marie, Schrag, Delphine, Didelot, Gérard, Bosson, Nicolas, Costes, Nessie, Cons, Laura, Buatois, Vanessa, Johnson, Zoe, Ferlin, Walter, Masternak, Krzysztof, Kosco-Vilbois, Marie
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Pub. Group 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4339886/
https://ncbi.nlm.nih.gov/pubmed/25672245
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms7113
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