Systemic levels of neuropeptide Y and dipeptidyl peptidase activity in Ewing sarcoma patients – associations with tumor phenotype and survival

BACKGROUND: Ewing sarcoma (ES) is driven by fusion of the EWS gene with an ETS transcription factor, most often FLI1. Neuropeptide Y (NPY) is an EWS-FLI1 transcriptional target. NPY is highly expressed in ES and exerts opposing effects, ranging from ES cell death to angiogenesis and cancer stem cell...

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Pubblicato in:Cancer
Autori principali: Tilan, Jason U., Krailo, Mark, Barkauskas, Donald A., Galli, Susana, Mtaweh, Haifa, Long, Jessica, Wang, Hongkun, Hawkins, Kirsten, Lu, Congyi, Jeha, Dima, Izycka-Swieszewska, Ewa, Lawlor, Elizabeth R., Toretsky, Jeffrey A., Kitlinska, Joanna
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2014
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4339539/
https://ncbi.nlm.nih.gov/pubmed/25387699
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cncr.29090
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