Phase 1 trial and pharmacokinetic study of the oral platinum analog satraplatin in children and young adults with refractory solid tumors including brain tumors

BACKGROUND: Based on pre-clinical and clinical activity in adult refractory tumors, and absence of significant neuro-, nephro-, or oto-toxicity, we conducted a pediatric phase 1 trial to determine the toxicities, maximum tolerated dose (MTD), and pharmacokinetics of satraplatin, an oral platinum ana...

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Detalhes bibliográficos
Publicado no:Pediatr Blood Cancer
Main Authors: Akshintala, Srivandana, Marcus, Leigh, Warren, Katherine E., Murphy, Robert F., Sissung, Tristan M., Srivastava, Anjali, Goodspeed, Wendy J., Goodwin, Anne, Brewer, Carmen C., Zalewski, Christopher, King, Kelly A., Kim, AeRang, Figg, William D., Widemann, Brigitte C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4339515/
https://ncbi.nlm.nih.gov/pubmed/25556988
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pbc.25344
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