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Hypoxia and free radicals: role in tumor progression and the use of engineering-based platforms to address these relationships

Hypoxia is a feature of all solid tumors, contributing to tumor progression and therapy resistance. Through stabilization of the hypoxia-inducible factor 1 alpha (HIF-1α), hypoxia activates the transcription of a number of genes which sustain tumor progression. Since the seminal discovery of HIF-1α...

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Bibliografiske detaljer
Udgivet i:Free Radic Biol Med
Main Authors: Hielscher, Abigail, Gerecht, Sharon
Format: Artigo
Sprog:Inglês
Udgivet: 2014
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4339408/
https://ncbi.nlm.nih.gov/pubmed/25257256
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2014.09.015
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