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Hypoxia and free radicals: role in tumor progression and the use of engineering-based platforms to address these relationships
Hypoxia is a feature of all solid tumors, contributing to tumor progression and therapy resistance. Through stabilization of the hypoxia-inducible factor 1 alpha (HIF-1α), hypoxia activates the transcription of a number of genes which sustain tumor progression. Since the seminal discovery of HIF-1α...
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| 出版年: | Free Radic Biol Med |
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| 主要な著者: | , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2014
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4339408/ https://ncbi.nlm.nih.gov/pubmed/25257256 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2014.09.015 |
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