Quantifying the Microvascular Origin of BOLD-fMRI from First Principles with Two-Photon Microscopy and an Oxygen-Sensitive Nanoprobe

The blood oxygenation level-dependent (BOLD) contrast is widely used in functional magnetic resonance imaging (fMRI) studies aimed at investigating neuronal activity. However, the BOLD signal reflects changes in blood volume and oxygenation rather than neuronal activity per se. Therefore, understand...

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Publicado en:J Neurosci
Autores principales: Gagnon, Louis, Sakadžić, Sava, Lesage, Frédéric, Musacchia, Joseph J., Lefebvre, Joël, Fang, Qianqian, Yücel, Meryem A., Evans, Karleyton C., Mandeville, Emiri T., Cohen-Adad, Jülien, Polimeni, Jon̈athan R., Yaseen, Mohammad A., Lo, Eng H., Greve, Douglas N., Buxton, Richard B., Dale, Anders M., Devor, Anna, Boas, David A.
Formato: Artigo
Lenguaje:Inglês
Publicado: Society for Neuroscience 2015
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Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4339366/
https://ncbi.nlm.nih.gov/pubmed/25716864
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3555-14.2015
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