Quantifying the Microvascular Origin of BOLD-fMRI from First Principles with Two-Photon Microscopy and an Oxygen-Sensitive Nanoprobe

The blood oxygenation level-dependent (BOLD) contrast is widely used in functional magnetic resonance imaging (fMRI) studies aimed at investigating neuronal activity. However, the BOLD signal reflects changes in blood volume and oxygenation rather than neuronal activity per se. Therefore, understand...

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Pubblicato in:J Neurosci
Autori principali: Gagnon, Louis, Sakadžić, Sava, Lesage, Frédéric, Musacchia, Joseph J., Lefebvre, Joël, Fang, Qianqian, Yücel, Meryem A., Evans, Karleyton C., Mandeville, Emiri T., Cohen-Adad, Jülien, Polimeni, Jon̈athan R., Yaseen, Mohammad A., Lo, Eng H., Greve, Douglas N., Buxton, Richard B., Dale, Anders M., Devor, Anna, Boas, David A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Society for Neuroscience 2015
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4339366/
https://ncbi.nlm.nih.gov/pubmed/25716864
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3555-14.2015
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