Migraine Mutations Impair Hippocampal Learning Despite Enhanced Long-Term Potentiation

To explain cognitive and memory difficulties observed in some familial hemiplegic migraine (FHM) patients, we examined hippocampal neurotransmission and plasticity in knock-in mice expressing the FHM type 1 (FHM1) R192Q gain-of function mutation in the CACNA1A gene that encodes the α(1A) subunit of...

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Publicado no:J Neurosci
Main Authors: Dilekoz, Ergin, Houben, Thijs, Eikermann-Haerter, Katharina, Balkaya, Mustafa, Lenselink, A. Mariette, Whalen, Michael J., Spijker, Sabine, Ferrari, Michel D., van den Maagdenberg, Arn M.J.M., Ayata, Cenk
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2015
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4339352/
https://ncbi.nlm.nih.gov/pubmed/25716839
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2630-14.2015
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