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Antibody effector functions mediated by Fcγ receptors are compromised during chronic viral infection

T cell dysfunction is well documented during chronic viral infections but little is known about functional abnormalities in humoral immunity. Here we report that mice chronically infected with lymphocytic choriomeningitis virus (LCMV) exhibit a severe defect in Fcγ-receptor (FcγR)-mediated antibody...

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Detalhes bibliográficos
Publicado no:Immunity
Main Authors: Wieland, Andreas, Shashidharamurthy, Rangaiah, Kamphorst, Alice O., Han, Jin-Hwan, Aubert, Rachael D., Choudhury, Biswa P., Stowell, Sean R., Lee, Junghwa, Punkosdy, George A., Shlomchik, Mark J., Selvaraj, Periasamy, Ahmed, Rafi
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4339104/
https://ncbi.nlm.nih.gov/pubmed/25680276
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2015.01.009
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