SOD1 silencing in motoneurons or glia rescues neuromuscular function in ALS mice

OBJECTIVE: Amyotrophic lateral sclerosis is an incurable disorder mainly characterized by motoneuron degeneration. Mutations in the superoxide dismutase 1 (SOD1) gene account for 20% of familial forms of the disease. Mutant SOD1 exerts multiple pathogenic effects through the gain of toxic properties...

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Dettagli Bibliografici
Pubblicato in:Ann Clin Transl Neurol
Autori principali: Dirren, Elisabeth, Aebischer, Julianne, Rochat, Cylia, Towne, Christopher, Schneider, Bernard L, Aebischer, Patrick
Natura: Artigo
Lingua:Inglês
Pubblicazione: BlackWell Publishing Ltd 2015
Soggetti:
Research Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4338957/
https://ncbi.nlm.nih.gov/pubmed/25750921
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/acn3.162
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