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SOD1 silencing in motoneurons or glia rescues neuromuscular function in ALS mice
OBJECTIVE: Amyotrophic lateral sclerosis is an incurable disorder mainly characterized by motoneuron degeneration. Mutations in the superoxide dismutase 1 (SOD1) gene account for 20% of familial forms of the disease. Mutant SOD1 exerts multiple pathogenic effects through the gain of toxic properties...
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| Publicado no: | Ann Clin Transl Neurol |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BlackWell Publishing Ltd
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4338957/ https://ncbi.nlm.nih.gov/pubmed/25750921 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/acn3.162 |
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