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Deficiency of Akt1, but not Akt2, attenuates the development of pulmonary hypertension

Pulmonary vascular remodeling, mainly attributable to enhanced pulmonary arterial smooth muscle cell proliferation and migration, is a major cause for elevated pulmonary vascular resistance and pulmonary arterial pressure in patients with pulmonary hypertension. The signaling cascade through Akt, co...

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Detalhes bibliográficos
Publicado no:Am J Physiol Lung Cell Mol Physiol
Main Authors: Tang, Haiyang, Chen, Jiwang, Fraidenburg, Dustin R., Song, Shanshan, Sysol, Justin R., Drennan, Abigail R., Offermanns, Stefan, Ye, Richard D., Bonini, Marcelo G., Minshall, Richard D., Garcia, Joe G. N., Machado, Roberto F., Makino, Ayako, Yuan, Jason X.-J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4338938/
https://ncbi.nlm.nih.gov/pubmed/25416384
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00242.2014
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