PKC-α contributes to high NaCl-induced activation of NFAT5 (TonEBP/OREBP) through MAPK ERK1/2

High NaCl in the renal medullary interstitial fluid powers the concentration of urine but can damage cells. The transcription factor nuclear factor of activated T cells 5 (NFAT5) activates the expression of osmoprotective genes. We studied whether PKC-α contributes to the activation of NFAT5. PKC-α...

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Detalhes bibliográficos
Publicado no:Am J Physiol Renal Physiol
Main Authors: Wang, Hong, Ferraris, Joan D., Klein, Janet D., Sands, Jeff M., Burg, Maurice B., Zhou, Xiaoming
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2014
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4338925/
https://ncbi.nlm.nih.gov/pubmed/25391900
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00471.2014
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